What animal shots tell us about MOTS-c peptide amounts.
Mouse tests used belly shots over several weeks. No study has proved a safe amount, schedule, or time in the human body.
What Mouse Amounts Do Not Set for You
Mouse tests measured sugar use and strength after MOTS-c shots. They didn't measure a safe amount for people.
Researchers gave shots into the open space inside each mouse's belly. The amounts ranged from half a milligram to fifteen milligrams per kilogram.
Tests lasted weeks, with shots daily or three times weekly. Those schedules do not tell your doctor what amount to use.
Researchers haven't measured half-life in people. Half-life means how long half the MOTS-c takes to leave your body.
What Each Mouse Test Gave and Measured
Researchers chose different amounts for different mouse tests. In 2015, mice got 0.5 milligrams per kilogram of body weight daily for about 8 weeks.
A 7-day test used 5 milligrams per kilogram each day [1]. The 2021 strength test used 15 milligrams per kilogram daily, or 15 milligrams three times weekly [2].
A bone study used 5 milligrams per kilogram each day for 12 weeks [9]. Every amount above was tested in mice, never people.
Each amount was based on one kilogram of mouse weight. Doctors have no tested formula for a human amount [4].
The range was 0.5 to 15 milligrams per kilogram each day. That is thirty times as much at the high end.
The 0.5 milligram test measured sugar use and body weight [1]. The 15 milligram test measured strength in old mice.
Another test used 15 milligrams per kilogram three times weekly [2]. The papers don't prove that the larger amount was needed.
Your age, kidneys, liver, and other drugs can change what happens. Mouse work can't answer those human questions.
What We Know About Time in the Body
Human studies haven't measured the MOTS-c half-life. That means the time for half the MOTS-c to leave your body.
Mouse studies used daily or three-times-a-week shots [1][2]. One paper treated the schedule as a hint of a short stay [2].
A schedule is not a clock. It can't give an exact time for you.
Some tests changed MOTS-c so more entered tissue [4]. That changed version can't show how long plain MOTS-c stays in people.
How Long May MOTS-c Stay in Your Body?
No human study gives an answer. Repeated animal shots only suggest a quick exit from the blood [1][2].
Nobody knows the true time without a human blood study. A sales claim giving exact hours goes past the published work.
Where Mouse Tests Put the MOTS-c Shot
Where Researchers Gave the Mouse Shots
Most tests put the shot into the open space inside a mouse's belly. That is common in mouse work, not normal human care [1][2].
Some tests placed MOTS-c beneath the skin with a shot. Other work added MOTS-c to cells living in dishes [4].
A skin shot and a mouse belly shot enter the body differently. The body may take up and remove MOTS-c at different speeds.
Lab suppliers often provide MOTS-c as dry powder. Mixing and storage can differ by supplier and study [4].
There is no FDA-approved MOTS-c product for people. Animal shots and amounts can't become directions for you.
What to Watch for When Human Safety Is Unknown
No completed human study tells us the side effects of taking MOTS-c. Human work only measured MOTS-c made by the body [14].
Missing harm reports don't mean MOTS-c is safe. They mean the needed safety studies haven't been done.
Mouse studies used 0.5–15 milligrams per kilogram each day [1][2]. Simple math can't turn those animal amounts into a human dose.
A lab vial may differ in strength, contents, and freedom from germs. It doesn't meet the same rules as an approved medicine.
A clean label can't prove what is inside a research vial. Your doctor also has no human study to weigh against that risk.
One study linked family-passed DNA differences with diabetes risk in some groups [7]. It doesn't show that taking MOTS-c caused that risk.
The finding does warn that people may not respond alike. Harm could also come from MOTS-c, the vial, or the shot.
Published work doesn't say how often any harm occurs. The law and sport page explains the top-level sport ban.